Background: Patients who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 HER2 -targeted therapy have a worse prognosis than those who have no residual cancer. Trastuzumab emtansine T-DM1 , an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine DM1 , a maytansine derivative and microtubule inhibitor, provides benefit in patients with metastatic breast cancer that was previously treated with chemotherapy plus HER2-targeted therapy. Methods: We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane with or without anthracycline and trastuzumab. Patients were randomly assigned to receive adjuvant T-DM1 or trastuzumab for 14 cycles.
Chemotherapy for Breast Cancer
Stage 1 Breast Cancer: Diagnosis, Treatments, and Prognosis
Not all breast cancers are the same. Understand what type of breast cancer you have and how it differs from other types of breast cancer. Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor. Using a tissue sample from your breast biopsy or using your tumor if you've already undergone surgery, your medical team determines your breast cancer type. This information helps your doctor decide which treatment options are most appropriate for you. Each breast contains 15 to 20 lobes of glandular tissue, arranged like the petals of a daisy.
An Overview of Stage 2 Breast Cancer
Breast cancers that have spread into surrounding breast tissue are known as invasive breast cancer. Most breast cancers are invasive, but there are different types of invasive breast cancer. The two most common are invasive ductal carcinoma and invasive lobular carcinoma. Inflammatory breast cancer and triple negative breast cancer are also types of invasive breast cancer. This is the most common type of breast cancer.
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