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Androgen insensitivity syndrome
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Disorders of the sex chromosome like disorders of the autosomes can be either numerical or structural, and can be present in all cells or in a mosaic form. Clinical indications that should raise suspicions of a sex chromosome abnormality are:. These disorders are considered very common with incidence of about — Phenotypes associated with sex chromosome disorders are less severe than autosomal defects and this is mainly due to X chromosome inactivation , as well as the fact that Y chromosomes have a low gene content.
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The presence of extra X chromosomes in a cell is compensated for by X-inactivation in which all but one X chromosome are silenced. Humans display dramatic deleterious effects with autosomal trisomies and monosomies. Therefore, it may seem counterintuitive that human females and males can function normally, despite carrying different numbers of the X chromosome.
The physical difference between male and female in animals. In the human species the male is called man, q. Some human beings whose sexual organs are somewhat imperfect, have acquired the name of hermaphrodite. In the civil state the sex creates a difference among individuals.