The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. There is a disparity in prevalence of CVD between pre- and post-menopausal women, and the difference can be attributed to estrogen levels. This regulation can increase endothelial function and arterial perfusion , both of which are important to myocyte health. Similar to CVD, post-menopausal women have an increased risk of developing Alzheimer's disease AD due to a loss of estrogen, which affects proper aging of the hippocampus , neural survival and regeneration , and amyloid metabolism.
Hormone Therapy for Breast Cancer
HER2 Positive and Negative Breast Cancers: Aggressiveness, Treatment, and Survival
Metrics details. Endocrine therapy is the mainstay of treatment in estrogen receptor-positive breast cancers and significantly reduces disease recurrence and breast cancer-related mortality. However, acquired resistance to therapy has been noted in nearly one-third of women treated with tamoxifen and other endocrine therapies. Mutations in the estrogen receptor have long been speculated to play a role in endocrine therapy resistance but have been rarely detected. However, recent studies utilizing next-generation sequencing on estrogen receptor-positive, metastatic clinical samples have revealed that recurrent ESR1 mutations are far more frequent than previously thought and may play an important role in acquired endocrine therapy resistance.
HER2 Positive vs. HER2 Negative Breast Cancer
Read terms. Member contributors included Ruth Farrell, MD. This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed.
If you had to name one of your biggest health fears, would breast cancer be top of your list? Because according to the American Cancer Society, breast cancer is diagnosed in 1 in 7 women. If you gather a small group of your girlfriends, someone is going to get it.