The mammalian gut microbiota is considered to be determined mostly by diet, while the effect of genotype is still controversial. Here, we examined the effect of genotype on the gut microbiota in normal populations, exhibiting only natural polymorphisms, and evaluated this effect in comparison to the effect of sex. DNA fingerprinting approaches were used to profile the gut microbiota of eight different recombinant inbred mouse lines of the collaborative cross consortium, whose level of genetic diversity mimics that of a natural human population. Analyses based on automated ribosomal internal transcribed spacer analysis demonstrated significant higher similarity of the gut microbiota composition within mouse lines than between them or within same-gender groups.
Why Sex Matters in Mouse Models | The Scientist Magazine®
In many species, reproduction requires detecting, recognizing, and courting a potential mate. Progress through these stages is guided by cues involving a wide range of sensory systems. Here we explore the tasks of detection, recognition, and response in terms of the ultrasonic songs of male mice presented with odor cues contained in urine. We find that the quantity of singing, more so than specific features of the songs, varies depending upon the odor cue. For experiencedmale mice, responses to female odor cues depend only on the concentration of female cues and are independent of the presence of male cues.
Sex-change mice research could help humans, say scientists
Metrics details. To this end, we highlight advances in AD and in sex and hormone biology, discuss what these advances mean for merging the two fields, review the current mouse model literature, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in this important area. Unraveling human relevant pathways in sex and hormone-based biology may ultimately pave the way to novel and urgently needed treatments for AD and other neurodegenerative diseases. In , the Institute of Medicine advocated for expansion of neuroscience research to understand sex differences in the susceptibility and progression of key neurodegenerative conditions such as AD [ 1 ].
The Mouse. Additional sources of information. General The laboratory mouse, Mus musculus, belongs to the order Rodentia and family Muridae. The mouse is probably the most genetically and biologically characterized mammal in the world.